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ABRI / ITM2B

integral membrane protein 2B

Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42.Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.

Gene Name: integral membrane protein 2B
Synonyms: ITM2B, ABri/ADan amyloid peptide, ABRI, BRI, BRI2, E3-16, Integral membrane protein 2B, ImBRI2, FBD, Protein E25B, BRICD2B, BRICHOS domain containing 2B, Transmembrane protein BRI, E25B, Immature BRI2
Target Sequences: NM_021999 NP_068839.1 Q9Y287

☰ Filters
Antibodies (31)
Proteins (7)
Over-Expression Lysate (2)
Primary (31)
Recombinant (5)
ABRI / ITM2B (38)
Human (26)
Mouse (16)
Rat (2)
Bovine (1)
Horse (1)
Monkey (2)
Rabbit (5)
IHC (13)
IHC-P (4)
WB (27)
Flo (2)
ELISA (16)
IF (1)
Peptide-ELISA (1)
rabbit (21)
mouse (9)
goat (1)
Product Group
IHCPlus (1)
IgG (20)
IgG2a (2)
IgG2a,k (6)
monoclonal mc (8)
polyclonal pc (23)
OTI1C11 (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (13)
aa218-247 (7)
Internal (1)
aa146-245 (1)
aa224-238 (1)
No (38)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
ABRI / ITM2B Antibody - Anti-ITM2B antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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ABRI / ITM2B Goat anti-Human Polyclonal (aa224-238) Antibody
Bovine, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ABRI / ITM2B Antibody - Western blot analysis of extracts of various cell lines, using ITM2B antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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ABRI / ITM2B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ABRI / ITM2B Antibody - ITM2B Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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ABRI / ITM2B Rabbit anti-Human Polyclonal (aa218-247) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ABRI / ITM2B Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ITM2B mouse monoclonal antibody.
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ABRI / ITM2B Mouse anti-Human Monoclonal (OTI1C11) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABRI / ITM2B Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ITM2B mouse monoclonal antibody.
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ABRI / ITM2B Mouse anti-Human Monoclonal (Carrier-free) (OTI1C11) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
ABRI / ITM2B Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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ABRI / ITM2B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal (aa218-247) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
ABRI / ITM2B Rabbit anti-Mouse Polyclonal (aa218-247) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
ABRI / ITM2B Rabbit anti-Mouse Polyclonal (aa218-247) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
ABRI / ITM2B Rabbit anti-Mouse Polyclonal (aa218-247) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
ABRI / ITM2B Rabbit anti-Mouse Polyclonal (aa218-247) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
ABRI / ITM2B Rabbit anti-Mouse Polyclonal (aa218-247) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
ABRI / ITM2B Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using ITM2B Polyclonal Antibody at dilution of 1:35(×200)
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (aa146-245) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
Select
ABRI / ITM2B Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
ABRI / ITM2B Antibody - Western blot analysis of Mouse lung tissue lysate  using ITM2B Polyclonal Antibody at dilution of 1:400
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$749
Select
ABRI / ITM2B Rabbit anti-Human Polyclonal (PE) Antibody
Rabbit, Mouse, Human
WB
PE Conjugated
100 µl/$937
Select
ABRI / ITM2B Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
Viewing 1-25 of 38 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).