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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 396,129 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2199

LS-B2199 is a sheep anti-EGFR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-IL-10 Antibody (clone JES5-2A5) IHC-plus™ LS-B4913

LS-B4913 is a rat anti-IL-10 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About IL-10: IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. (more)

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Anti-DNASE1 / DNase I Antibody IHC-plus™ LS-B4846

LS-B4846 is a rabbit anti-DNASE1 / DNase I polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Anti-CAMK2 / CAMKII Antibody (aa509-558) LS-C119025

LS-C119025 is a rabbit anti-CAMK2 / CAMKII polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot. (more)

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Anti-SUV39H2 Antibody (C-Terminus) LS-C116360

LS-C116360 is a rabbit anti-SUV39H2 polyclonal antibody approved for use in Western blot.

About SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. (more)

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Anti-ROR1 Antibody IHC-plus™ LS-B3717

LS-B3717 is a goat anti-ROR1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About ROR1: ROR1 is a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. (more)

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Anti-CFH / Complement Factor H Antibody (clone OX-24) IHC-plus™ LS-B2889

LS-B2889 is a mouse anti-CFH / Complement Factor H monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About CFH / Complement Factor H: CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (more)

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Anti-CXCR4 Antibody (clone 12G5) IHC-plus™ LS-B1986

LS-B1986 is a mouse anti-CXCR4 monoclonal antibody approved for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. (more)

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Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) IHC-plus™ LS-B1836

LS-B1836 is a rabbit anti-SLC40A1 / Ferroportin-1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-Collagen III Antibody IHC-plus™ LS-B693

LS-B693 is a rabbit anti-Collagen III polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About Collagen III: Type-III Collagen is a fibrous scleroprotein in bone, cartilage, tendon, bone marrow stroma and other connective tissue. Mutations Collagen III are associated with type III and IV Ehlers-Danlos syndrome and with aortic and arterial aneurysms. (more)

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Anti-NES / Nestin Antibody (aa1484-1500) IHC-plus™ LS-B656

LS-B656 is a rabbit anti-NES / Nestin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About NES / Nestin: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. (more)

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Anti-TGFB1 / TGF Beta 1 Antibody (aa286-293) IHC-plus™ LS-B655

LS-B655 is a rabbit anti-TGFB1 / TGF Beta 1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About TGFB1 / TGF Beta 1: TGFB1 / TGF Beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. (more)

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Anti-Dipeptidylpeptidase 8 / DPP8 Antibody (N-Terminus) IHC-plus™ LS-A8035

LS-A8035 is a rabbit anti-Dipeptidylpeptidase 8 / DPP8 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About Dipeptidylpeptidase 8 / DPP8: Dipeptidylpeptidase 8 / DPP8 is a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. (more)

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Anti-APLNR/ Apelin Receptor / APJ Antibody (C-Terminus) IHC-plus™ LS-A65

LS-A65 is a rabbit anti-APLNR/ Apelin Receptor / APJ polyclonal antibody approved for use in Immunocytochemistry and Immunohistochemistry - Paraffin.

About APLNR/ Apelin Receptor / APJ: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. (more)

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Anti-IFN Gamma / Interferon Gamma Antibody (aa24-166) LS-C294753

LS-C294753 is a rabbit anti-IFN Gamma / Interferon Gamma polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About IFN Gamma / Interferon Gamma: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (more)

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Anti-Fgf15 Antibody (aa25-218) LS-C293897

LS-C293897 is a rabbit anti-Fgf15 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Fgf15: Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19. (more)

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Anti-SRSF6 / SRP55 Antibody (aa250-300) LS-C290327

LS-C290327 is a rabbit anti-SRSF6 / SRP55 polyclonal antibody approved for use in Immunoprecipitation and Western blot.

About SRSF6 / SRP55: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. (more)

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Anti-TJP1 / ZO-1 Antibody (C-Terminus) IHC-plus™ LS-B9774

LS-B9774 is a goat anti-TJP1 / ZO-1 polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About TJP1 / ZO-1: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. (more)

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Anti-MSLN / Mesothelin Antibody (clone B35) LS-C179484

LS-C179484 is a rat anti-MSLN / Mesothelin monoclonal antibody approved for use in Flow Cytometry.

About MSLN / Mesothelin: This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. (more)

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Anti-HEXB Antibody (aa481-530) IHC-plus™ LS-B8401

LS-B8401 is a rabbit anti-HEXB polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About HEXB: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-FABP7 / BLBP / MRG Antibody (aa1-132, clone AT1D1) IHC-plus™ LS-B6684

LS-B6684 is a mouse anti-FABP7 / BLBP / MRG monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FABP7 / BLBP / MRG: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. (more)

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Anti-PDGFRA / PDGFR Alpha Antibody (aa1035-1053) IHC-plus™ LS-B6056

LS-B6056 is a rabbit anti-PDGFRA / PDGFR Alpha polyclonal antibody approved for use in Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About PDGFRA / PDGFR Alpha: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. (more)

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Anti-TSPO / PBR Antibody (aa156-169) IHC-plus™ LS-B5755

LS-B5755 is a goat anti-TSPO / PBR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TSPO / PBR: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. (more)

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Anti-CD274 / B7-H1 / PD-L1 Antibody (clone ANC6H1, Azide-free) LS-C134638

LS-C134638 is a mouse anti-CD274 / B7-H1 / PD-L1 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Flow Cytometry.

About CD274 / B7-H1 / PD-L1: CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. Expression of CD274 in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. (more)

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Anti-CD17 / Lactosylceramide Antibody (clone Huly-m13, FITC) LS-C134309

LS-C134309 is a Fluorescein mouse anti-CD17 / Lactosylceramide monoclonal antibody approved for use in Flow Cytometry. (more)

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Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 8G8) LS-C340014

LS-C340014 is a mouse anti-PDCD1LG2 / CD273 / PD-L2 monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PDCD1LG2 / CD273 / PD-L2: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. (more)

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Anti-tdTomato Antibody LS-C340696

LS-C340696 is a goat anti-tdTomato polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot. (more)

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Anti-ANGPTL4 Antibody (Fibrinogen-like domain) LS-C345010

LS-C345010 is a rabbit anti-ANGPTL4 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. (more)

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Most Popular ELISA Kits
Human SDF1 / CXCL12 ELISA Kit (Sandwich ELISA) - LS-F695

LS-F695 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SDF1 / CXCL12 in samples of Cell Lysates, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SDF1 / CXCL12 as low as 32 picograms per milliliter.

About SDF1 / CXCL12: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. (more)

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Human Phospho-NFKB1 / NF-Kappa-B (Ser337) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F891

LS-F891 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NFKB1 / NF-Kappa-B in samples of Cell Lysates and Nuclear Lysates. It is based upon a DNA Binding Phosphorylation assay principle.

About NFKB1 / NF-Kappa-B: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (more)

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Mouse/Human/Rat Phospho-SMAD3 (Ser213) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F926

LS-F926 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SMAD3 in samples of Cell Lysates and Nuclear Lysates. It is based upon a DNA Binding Phosphorylation assay principle.

About SMAD3: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. (more)

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Human GH / Growth Hormone ELISA Kit (Sandwich ELISA) - LS-F2589

LS-F2589 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GH / Growth Hormone in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GH / Growth Hormone as low as 15.6 picograms per milliliter.

About GH / Growth Hormone: GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. (more)

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Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 156 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Canine CST3 / Cystatin C ELISA Kit (Sandwich ELISA) - LS-F3490

LS-F3490 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Canine CST3 / Cystatin C in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CST3 / Cystatin C as low as 10.24 picograms per milliliter.

About CST3 / Cystatin C: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. (more)

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Mouse Angiotensin II ELISA Kit (Competitive EIA) - LS-F3954

LS-F3954 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Angiotensin II in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 24.69 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Human AQP3 / Aquaporin 3 ELISA Kit (Sandwich ELISA) - LS-F4074

LS-F4074 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human AQP3 / Aquaporin 3 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AQP3 / Aquaporin 3 as low as 0.059 nanograms per millilter.

About AQP3 / Aquaporin 3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. (more)

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Rat NOS2 / iNOS ELISA Kit (Sandwich ELISA) - LS-F4109

LS-F4109 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat NOS2 / iNOS in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NOS2 / iNOS as low as 1.56 nanograms per millilter.

About NOS2 / iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. (more)

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Rat APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F4180

LS-F4180 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat APOA1 / Apolipoprotein A 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of APOA1 / Apolipoprotein A 1 as low as 0.21 nanograms per millilter.

About APOA1 / Apolipoprotein A 1: APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. (more)

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Human Neuropeptide S / NPS ELISA Kit (Competitive EIA) - LS-F4298

LS-F4298 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Neuropeptide S / NPS in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Neuropeptide S / NPS as low as 12.35 picograms per milliliter.

About Neuropeptide S / NPS: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. (more)

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Human LF / LTF / Lactoferrin ELISA Kit (Sandwich ELISA) - LS-F4350

LS-F4350 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LF / LTF / Lactoferrin in samples of Breast Milk, Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LF / LTF / Lactoferrin as low as 0.313 nanograms per millilter.

About LF / LTF / Lactoferrin: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. (more)

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Human LRP1 / CD91 ELISA Kit (Sandwich ELISA) - LS-F4389

LS-F4389 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LRP1 / CD91 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of LRP1 / CD91 as low as 62.5 picograms per milliliter.

About LRP1 / CD91: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A. (more)

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Mouse APOE / Apolipoprotein E ELISA Kit (Sandwich ELISA) - LS-F4714

LS-F4714 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse APOE / Apolipoprotein E in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of APOE / Apolipoprotein E as low as 15.63 nanograms per millilter.

About APOE / Apolipoprotein E: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. (more)

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Rat CCL17 / TARC ELISA Kit (Sandwich ELISA) - LS-F4911

LS-F4911 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CCL17 / TARC in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CCL17 / TARC as low as 15.63 picograms per milliliter.

About CCL17 / TARC: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. (more)

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Mouse NGF ELISA Kit (Sandwich ELISA) - LS-F5156

LS-F5156 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NGF in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NGF as low as 15.63 picograms per milliliter.

About NGF: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. (more)

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Pig MMP9 / Gelatinase B ELISA Kit (Sandwich ELISA) - LS-F5334

LS-F5334 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig MMP9 / Gelatinase B in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP9 / Gelatinase B as low as 3.12 nanograms per millilter.

About MMP9 / Gelatinase B: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (more)

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Human CRH / CRF ELISA Kit (Competitive EIA) - LS-F5352

LS-F5352 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CRH / CRF in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 12.35 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Chicken LYZ / Lysozyme ELISA Kit (Sandwich ELISA) - LS-F5726

LS-F5726 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Chicken LYZ / Lysozyme in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LYZ / Lysozyme as low as 0.625 nanograms per millilter.

About LYZ / Lysozyme: LYZ / Lysozyme is human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. (more)

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Human EREG / Epiregulin ELISA Kit (Sandwich ELISA) - LS-F5753

LS-F5753 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human EREG / Epiregulin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of EREG / Epiregulin as low as 15.6 picograms per milliliter.

About EREG / Epiregulin: Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. (more)

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Mouse/Human/Rat NOG / Noggin ELISA Kit (Sandwich ELISA) - LS-F5920

LS-F5920 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NOG / Noggin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NOG / Noggin as low as 0.156 nanograms per millilter.

About NOG / Noggin: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. (more)

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Rhesus monkey IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F6091

LS-F6091 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rhesus monkey IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 15.63 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Mouse Fibrin Degradation Product D-Dimer ELISA Kit (Competitive EIA) - LS-F6179

LS-F6179 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Fibrin Degradation Product D-Dimer in samples of Plasma. It is based upon a Competitive EIA assay principle and can be used to detect levels of Fibrin Degradation Product D-Dimer as low as 12.35 nanograms per millilter. (more)

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Human TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F6459

LS-F6459 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TOP1 / Topoisomerase I in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TOP1 / Topoisomerase I as low as 0.156 nanograms per millilter.

About TOP1 / Topoisomerase I: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Human PIK3CD / PI3K Delta ELISA Kit (Sandwich ELISA) - LS-F7042

LS-F7042 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PIK3CD / PI3K Delta in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PIK3CD / PI3K Delta as low as 0.313 nanograms per millilter.

About PIK3CD / PI3K Delta: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. (more)

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Rat TNNT2 / CTNT ELISA Kit (Sandwich ELISA) - LS-F7134

LS-F7134 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat TNNT2 / CTNT in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNNT2 / CTNT as low as 15.63 picograms per milliliter.

About TNNT2 / CTNT: TNNT2 / CTNT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. (more)

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Mouse CHIT1 / Chitotriosidase ELISA Kit (Sandwich ELISA) - LS-F7277

LS-F7277 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CHIT1 / Chitotriosidase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CHIT1 / Chitotriosidase as low as 0.156 nanograms per millilter.

About CHIT1 / Chitotriosidase: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. (more)

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Pig MMP2 ELISA Kit (Sandwich ELISA) - LS-F7320

LS-F7320 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig MMP2 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP2 as low as 31.2 picograms per milliliter.

About MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. (more)

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Mouse JAG1 / Jagged 1 ELISA Kit (Sandwich ELISA) - LS-F7394

LS-F7394 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse JAG1 / Jagged 1 in samples of Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of JAG1 / Jagged 1 as low as 15.63 picograms per milliliter.

About JAG1 / Jagged 1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). (more)

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Mouse TPH2 ELISA Kit (Sandwich ELISA) - LS-F7454

LS-F7454 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse TPH2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPH2 as low as 0.156 nanograms per millilter.

About TPH2: TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. (more)

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Mouse LOXL2 ELISA Kit (Sandwich ELISA) - LS-F7478

LS-F7478 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LOXL2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LOXL2 as low as 0.156 nanograms per millilter.

About LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. (more)

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Mouse FTH1 / Ferritin Heavy Chain ELISA Kit (Sandwich ELISA) - LS-F7520

LS-F7520 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse FTH1 / Ferritin Heavy Chain in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FTH1 / Ferritin Heavy Chain as low as 0.156 nanograms per millilter.

About FTH1 / Ferritin Heavy Chain: FTH1 / Ferritin Heavy Chain is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. (more)

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Human COL15A1 / Collagen XV Alpha 1 ELISA Kit (Sandwich ELISA) - LS-F7575

LS-F7575 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human COL15A1 / Collagen XV Alpha 1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of COL15A1 / Collagen XV Alpha 1 as low as 3.13 nanograms per millilter.

About COL15A1 / Collagen XV Alpha 1: COL15A1 / Collagen XV Alpha 1 is the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (more)

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Mouse NODAL ELISA Kit (Sandwich ELISA) - LS-F7607

LS-F7607 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NODAL in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NODAL as low as 15.63 picograms per milliliter.

About NODAL: Essential for mesoderm formation and axial patterning during embryonic development. (more)

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Human OSTN / Musclin / Osteocrin ELISA Kit (Sandwich ELISA) - LS-F7799

LS-F7799 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human OSTN / Musclin / Osteocrin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of OSTN / Musclin / Osteocrin as low as 15.6 picograms per milliliter.

About OSTN / Musclin / Osteocrin: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. (more)

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Human FCGR3A / CD16A ELISA Kit (Sandwich ELISA) - LS-F7838

LS-F7838 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FCGR3A / CD16A in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FCGR3A / CD16A as low as 125 picograms per milliliter.

About FCGR3A / CD16A: FCGR3A / CD16A is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. (more)

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Rat APOC3 / Apolipoprotein C III ELISA Kit (Sandwich ELISA) - LS-F7840

LS-F7840 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat APOC3 / Apolipoprotein C III in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APOC3 / Apolipoprotein C III as low as 1.56 nanograms per millilter.

About APOC3 / Apolipoprotein C III: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. (more)

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Human SIRT6 / Sirtuin 6 ELISA Kit (Sandwich ELISA) - LS-F7874

LS-F7874 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SIRT6 / Sirtuin 6 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SIRT6 / Sirtuin 6 as low as 0.313 nanograms per millilter.

About SIRT6 / Sirtuin 6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. (more)

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Human UPK3A / UPK3 / Uroplakin III ELISA Kit (Sandwich ELISA) - LS-F8031

LS-F8031 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human UPK3A / UPK3 / Uroplakin III in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of UPK3A / UPK3 / Uroplakin III as low as 0.313 nanograms per millilter.

About UPK3A / UPK3 / Uroplakin III: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. (more)

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Rat CYP1A1 ELISA Kit (Sandwich ELISA) - LS-F8460

LS-F8460 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CYP1A1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYP1A1 as low as 0.129 nanograms per millilter.

About CYP1A1: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. (more)

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Rat UGT1A / UGT1A1 ELISA Kit (Sandwich ELISA) - LS-F8467

LS-F8467 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat UGT1A / UGT1A1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of UGT1A / UGT1A1 as low as 0.61 nanograms per millilter.

About UGT1A / UGT1A1: UGT1A / UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. (more)

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Pig FN1 / Fibronectin ELISA Kit (Sandwich ELISA) - LS-F8531

LS-F8531 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig FN1 / Fibronectin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FN1 / Fibronectin as low as 0.313 nanograms per millilter.

About FN1 / Fibronectin: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. (more)

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Rat POSTN / Periostin ELISA Kit (Sandwich ELISA) - LS-F8662

LS-F8662 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat POSTN / Periostin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of POSTN / Periostin as low as 31.2 picograms per milliliter.

About POSTN / Periostin: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX By similarity. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. (more)

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Mouse QSOX1 / QSCN6 ELISA Kit (Sandwich ELISA) - LS-F8712

LS-F8712 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse QSOX1 / QSCN6 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of QSOX1 / QSCN6 as low as 78.13 picograms per milliliter.

About QSOX1 / QSCN6: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation. (more)

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Human IL11RA ELISA Kit (Sandwich ELISA) - LS-F8919

LS-F8919 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL11RA in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL11RA as low as 0.156 nanograms per millilter.

About IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. (more)

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Mouse TPH1 / Tryptophan Hydroxylase ELISA Kit (Sandwich ELISA) - LS-F8942

LS-F8942 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse TPH1 / Tryptophan Hydroxylase in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPH1 / Tryptophan Hydroxylase as low as 0.156 nanograms per millilter.

About TPH1 / Tryptophan Hydroxylase: TPH1 / TPH encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. (more)

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Goat Progesterone ELISA Kit (Competitive EIA) - LS-F10141

LS-F10141 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Goat Progesterone in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Progesterone as low as 0.4 nanograms per millilter. (more)

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Rat CYP1A2 ELISA Kit (Sandwich ELISA) - LS-F11188

LS-F11188 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CYP1A2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYP1A2 as low as 0.312 nanograms per millilter.

About CYP1A2: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. (more)

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Mouse IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F11686

LS-F11686 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse IDO1 / IDO in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 0.78 nanograms per millilter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Human MFGE8 /Lactadherin ELISA Kit (Sandwich ELISA) - LS-F12031

LS-F12031 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MFGE8 /Lactadherin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MFGE8 /Lactadherin as low as 31.2 picograms per milliliter.

About MFGE8 /Lactadherin: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. (more)

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Human Mucin 2 / MUC2 ELISA Kit (Sandwich ELISA) - LS-F12102

LS-F12102 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Mucin 2 / MUC2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Mucin 2 / MUC2 as low as 0.156 nanograms per millilter.

About Mucin 2 / MUC2: Mucin 2 / MUC2 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. (more)

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Mouse F11 / FXI / Factor XI ELISA Kit (Sandwich ELISA) - LS-F13175

LS-F13175 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse F11 / FXI / Factor XI in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of F11 / FXI / Factor XI as low as 0.312 nanograms per millilter.

About F11 / FXI / Factor XI: F11 / FXI / Factor XI is coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F21017

LS-F21017 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLIT2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SLIT2 as low as 0.16 nanograms per millilter.

About SLIT2: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. (more)

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Human NPHS1 / Nephrin ELISA Kit (Sandwich ELISA) - LS-F21185

LS-F21185 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human NPHS1 / Nephrin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NPHS1 / Nephrin as low as 0.156 nanograms per millilter.

About NPHS1 / Nephrin: NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. (more)

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Rat ALPL / Alkaline Phosphatase ELISA Kit (Sandwich ELISA) - LS-F21496

LS-F21496 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ALPL / Alkaline Phosphatase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ALPL / Alkaline Phosphatase as low as 0.16 nanograms per millilter.

About ALPL / Alkaline Phosphatase: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. (more)

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Human TNC / Tenascin C ELISA Kit (Sandwich ELISA) - LS-F22079

LS-F22079 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNC / Tenascin C in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNC / Tenascin C as low as 0.31 nanograms per millilter.

About TNC / Tenascin C: Tenascin C (TNC) is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. TNC has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One mechanism to explain this may come from its ability to bind to the extracellular matrix glycoprotein fibronectin and block fibronectin's interactions with specific syndecans. The expression of tenascin-C in the stroma of certain tumors is associated with a poor prognosis. (more)

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Human Complement C4 ELISA Kit (Sandwich ELISA) - LS-F22483

LS-F22483 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Complement C4 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C4 as low as 4.688 nanograms per millilter.

About Complement C4: Complement component 4 is a protein involved in the complement system. It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d. C4a is an anaphylatoxin. C4b forms part of C3-convertase, in conjunction with 2a, and can bind CR1. C4d has been identified as a biomarker for systemic lupus erythematosus. (more)

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Mouse TNT / Troponin T ELISA Kit (Sandwich ELISA) - LS-F23032

LS-F23032 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TNT / Troponin T in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNT / Troponin T as low as 15.63 picograms per milliliter. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F23444

LS-F23444 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 31.25 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Rat GUSB / Beta Glucuronidase ELISA Kit (Sandwich ELISA) - LS-F24073

LS-F24073 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat GUSB / Beta Glucuronidase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GUSB / Beta Glucuronidase as low as 78.13 picograms per milliliter.

About GUSB / Beta Glucuronidase: GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. (more)

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Human KRT15 / CK15 / Cytokeratin 15 ELISA Kit (Sandwich ELISA) - LS-F25187

LS-F25187 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human KRT15 / CK15 / Cytokeratin 15 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KRT15 / CK15 / Cytokeratin 15 as low as 31.25 picograms per milliliter.

About KRT15 / CK15 / Cytokeratin 15: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. (more)

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Rat Complement C1q ELISA Kit (Sandwich ELISA) - LS-F25231

LS-F25231 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Complement C1q in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C1q as low as 0.781 nanograms per millilter.

About Complement C1q: C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits (C1QA, C1QB, and C1QC). Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. (more)

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Human IL28B ELISA Kit (CLIA) - LS-F26382

LS-F26382 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL28B in samples of Plasma and Serum. It is based upon a Sandwich CLIA assay principle and can be used to detect levels of IL28B as low as 0.5 picograms per milliliter.

About IL28B: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. (more)

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Rat BMP4 ELISA Kit (CLIA) - LS-F26512

LS-F26512 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat BMP4 in samples of Plasma and Serum. It is based upon a Sandwich CLIA assay principle and can be used to detect levels of BMP4 as low as 5.12 picograms per milliliter.

About BMP4: BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. (more)

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Rat Acetylcholine ELISA Kit (Competitive EIA) - LS-F27870

LS-F27870 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Acetylcholine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Acetylcholine as low as 50 picograms per milliliter. (more)

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Mouse Angiotensin 1-7 ELISA Kit (Competitive EIA) - LS-F28147

LS-F28147 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Angiotensin 1-7 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin 1-7 as low as 50 picograms per milliliter. (more)

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Most Popular Proteins
Human PTGS2 / COX2 / COX-2 Recombinant (His) Protein - LS-G21094

LS-G21094 is a Human PTGS2 / COX2 / COX-2 recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About PTGS2 / COX2 / COX-2: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. (more)

Mouse PSCA Recombinant (His) Protein - LS-G23091

LS-G23091 is a Mouse PSCA recombinant protein generated in Yeast. This protein has been engineered to contain a His tag.

About PSCA: PSCA is a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. (more)

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Human RSV F0 Recombinant (His) Protein - LS-G23356

LS-G23356 is a Human RSV F0 recombinant protein generated in Yeast. This protein has been engineered to contain a His tag. (more)


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