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ZRANB1 / TRABID
zinc finger, RAN-binding domain containing 1
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
| Gene Name: | zinc finger, RAN-binding domain containing 1 |
| Synonyms: | ZRANB1, HTrabid, TRABID, Ubiquitin thioesterase ZRANB1, TRAF-binding protein domain |
| Target Sequences: | AJ252060 CAB64449.1 Q9UGI0 |
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