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ZNRF3
Zinc And Ring Finger 3
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
| Gene Name: | Zinc And Ring Finger 3 |
| Synonyms: | ZNRF3, BK747E2.3, RING finger protein 203, RNF203, Zinc/RING finger protein 3, KIAA1133, Zinc and ring finger 3 |
| Target Sequences: | AK025710 |
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