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ZNRF1
zinc and ring finger 1, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
| Gene Name: | zinc and ring finger 1, E3 ubiquitin protein ligase |
| Synonyms: | ZNRF1, NIN283, Zinc/RING finger protein 1, Zinc and ring finger 1, Nerve injury gene 283, Zinc and ring finger protein 1 |
| Target Sequences: | NM_032268 NP_115644.1 Q8ND25 |
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