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ZNF521
zinc finger protein 521
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
| Gene Name: | zinc finger protein 521 |
| Synonyms: | ZNF521, Evi3, EHZF, Zinc finger protein 521, LIP3, LYST-interacting protein 3 |
| Target Sequences: | AA461407 Q96K83 Q96K83 |
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