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ZNF423 / OAZ

zinc finger protein 423

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.

Gene Name: zinc finger protein 423
Family/Subfamily: Zinc Finger
Synonyms: ZNF423, Ebfaz, HOAZ, JBTS19, KIAA0760, NPHP14, OAZ, Zinc finger protein 423, ZFP423, Roaz, Zfp104
Target Sequences: NM_015069 NP_055884.2 Q2M1K9

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Proteins (2)
Over-Expression Lysate (2)
ZNF423 / OAZ (2)
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Myc-DDK (Flag) (2)
Human (1)
293T Cells (1)
HEK 293 Cells (1)
ZNF423 / OAZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
144.4 kDa
100 µg/$710
ZNF423 / OAZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
144.4 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).