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ZMIZ1 is a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.
Gene Name: | zinc finger, MIZ-type containing 1 |
Synonyms: | ZMIZ1, HZIMP10, MIZ, PIAS-like protein Zimp10, KIAA1224, RAI17, ZIMP10, Retinoic acid induced 17, RP11-519K18.1, TRAFIP10 |
Target Sequences: | AF070622 Q9ULJ6 Q9ULJ6 |
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