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ZKSCAN3 / ZNF306

zinc finger with KRAB and SCAN domains 3

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.

Gene Name:	zinc finger with KRAB and SCAN domains 3
Family/Subfamily:	Zinc Finger
Synonyms:	ZKSCAN3, DJ874C20.1, DJ874C20.1., KIAA0426, Zfp-47, ZFP306, Zinc finger protein 309, ZNF306, ZNF309, ZSCAN13, ZSCAN35, ZF47, Zinc finger protein 306, Zinc finger protein zfp47, Zfp47, Zinc finger protein 47 homolog
Target Sequences:	U71601 AAB16813.1

Publications (1)

Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells. Moses New-Aaron , Paul G Thomes , Murali Ganesan , Raghubendra Singh Dagur , Terrence M Donohue Jr , Kharbanda K Kusum , Larisa Y Poluektova, Natalia A Osna. Biomolecules. 2021 Oct;11:1497. [Full Text Article] [PubMed:34680130] [PMC:PMC8533635] Related Antibodies: LS-C501696.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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