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ZIC / ZIC1

Zic family member 1

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Gene Name: Zic family member 1
Synonyms: ZIC1, ZIC, Zic family member 1, Zinc finger protein ZIC 1, Zinc finger protein 201, ZNF201
Target Sequences: NM_003412 NP_003403.2 Q15915

Publications (1)

1
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Lipchina I, Elkabetz Y, Hafner M, Sheridan R, Mihailovic A, Tuschl T, Sander C, Studer L, Betel D. Genes & development. 2011 25:2173-86. [PubMed:22012620] [PMC:PMC3205587]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ZIC / ZIC1 (5)
No (5)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
ZIC / ZIC1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ZIC / ZIC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.1 kDa
20 µg/$150
ZIC / ZIC1 Protein
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E. coli
His, N-Terminal
48.1 kDa
50 µg/$419
ZIC / ZIC1 Protein
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E. coli
GST, N-terminus + His, C-terminus
76.1 kDa
50 µg/$419
ZIC / ZIC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.1 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).