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ZIC / ZIC1

Zic family member 1

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Gene Name:	Zic family member 1
Synonyms:	ZIC1, ZIC, Zic family member 1, Zinc finger protein ZIC 1, Zinc finger protein 201, ZNF201
Target Sequences:	NM_003412 NP_003403.2 Q15915

Publications (1)

Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Lipchina I, Elkabetz Y, Hafner M, Sheridan R, Mihailovic A, Tuschl T, Sander C, Studer L, Betel D. Genes & development. 2011 25:2173-86. [PubMed:22012620] [PMC:PMC3205587]

Mouse/Human ZIC / ZIC1 (Cell-Based ELISA) ELISA Kit - LS-F3017

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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