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ZGPAT

zinc finger, CCCH-type with G patch domain

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

Gene Name:	zinc finger, CCCH-type with G patch domain
Synonyms:	ZGPAT, DJ583P15.3, GPATC6, KIAA1847, RP4-583P15.3, ZC3HDC9, ZIP, ZC3H9, GPATCH6
Target Sequences:	NM_032527 CAC03670.1 Q8N5A5

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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