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ZFP36 / Tristetraprolin

ZFP36 ring finger protein

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Gene Name: ZFP36 ring finger protein
Synonyms: ZFP36, Protein TIS11A, Tristetraprolin, ZFP36 ring finger protein, TIS11, Zinc finger protein 36 homolog, TTP, NUP475, TIS11A, Tristetraproline, Zfp-36, G0S24, GOS24, RNF162A
Target Sequences: NM_003407 NP_003398.2 P26651

Publications (4)

1
RNA binding protein, tristetraprolin in a murine model of recurrent pregnancy loss. Khalaj K, Luna RL, de França ME, de Oliveira WH, Peixoto CA, Tayade C. Oncotarget. 2016 7:72486-72502. (Mouse) [Full Text Article] [PubMed:27732963] [PMC:PMC5341924] Related Antibodies: LS-B1572.
2
Differential expression of RNA-binding proteins in bronchial epithelium of stable COPD patients. Ricciardi L, Col JD, Casolari P, Memoli D, Conti V, Vatrella A, Vonakis BM, Papi A, Caramori G, Stellato C. International journal of chronic obstructive pulmonary disease. 2018 October;13:3173-3190. [Full Text Article] [PubMed:30349226] [PMC:PMC6190813] Related Antibodies: LS-B1572.
3
Tristetraprolin Is a Prognostic Biomarker for Poor Outcomes among Patients with Low-Grade Prostate Cancer. Rounbehler RJ, Berglund AE, Gerke T, Takhar MM, Awasthi S, Li W, Davicioni E, Erho NG, Ross AE, Schaeffer EM, Klein EA, Karnes RJ, Jenkins RB, Cleveland JL, Park JY, Yamoah K. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2018 November;27:1376-1383. [Full Text Article] [PubMed:30108099] [PMC:PMC6214732] Related Antibodies: LS-B5606.
4
Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. William J Sullivan, Peter J Mullen, Ernst W Schmid, Aimee Flores, Milica Momcilovic, Mark S Sharpley, David Jelinek, Andrew E Whiteley, Matthew B Maxwell, Blake R Wilde, Utpal Banerjee, Hilary A Coller, David B Shackelford, Daniel Braas, Donald E Ayer, Thomas Q de Aguiar Vallim, William E Lowry, Heather R Christofk. Cell. 2018 September;175:117-132.e21. [Full Text Article] [PubMed:30197082] [PMC:PMC6151140] Related Antibodies: LS-B1572.
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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ZFP36 / Tristetraprolin (4)
No (4)
GST (1)
GST, N-terminus + His, C-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
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ZFP36 / Tristetraprolin Protein
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E. coli
GST, N-terminus + His, C-terminus
58.8 kDa
50 µg/$419
ZFP36 / Tristetraprolin Protein - 12.5% SDS-PAGE of human ZFP36 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.4 kDa
10 µg/$479; 25 µg/$670
ZFP36 / Tristetraprolin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.8 kDa
20 µg/$150
ZFP36 / Tristetraprolin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.8 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).