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ZEB2 / SIP-1

zinc finger E-box binding homeobox 2

ZEB2 is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

Gene Name: zinc finger E-box binding homeobox 2
Synonyms: ZEB2, KIAA0569, SIP1, SMADIP1, ZFX1B, SIP-1, SMAD interacting protein 1, Smad-interacting protein 1, ZFHX1B, Zinc finger homeobox 1b, HSPC082
Target Sequences: NM_014795 NP_055610.1 O60315

Publications (4)

1
miR-215 functions as a tumor suppressor and directly targets ZEB2 in human non-small cell lung cancer. Hou Y, Zhen J, Xu X, Zhen K, Zhu B, Pan R, Zhao C. Oncology letters. 2015 10:1985-1992. (WB; Human) [Full Text Article] [PubMed:26622784] [PMC:PMC4579799] Related Antibodies: LS-C160768.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C160768.
3
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. Nevi L, Costantini D, Safarikia S, Di Matteo S, Melandro F, Berloco PB, Cardinale V. Cells. 2019 November;8:E1443. [Full Text Article] [PubMed:31731674] [PMC:PMC6912632]
4
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Shanzheng Yang, Enrique M Toledo, Pedro Rosmaninho, Changgeng Peng, Per Uhlén, Diogo S Castro, Ernest Arenas. Communications biology. 2018 Jun;1:75. [Full Text Article] [PubMed:30271956] [PMC:PMC6123725]
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Antibodies (59)
Primary (59)
ZEB2 / SIP-1 (59)
Human (50)
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IHC (35)
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rabbit (48)
mouse (10)
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monoclonal mc (10)
polyclonal pc (48)
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No (58)
Yes (1)
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ZEB2 / SIP-1 Goat anti-Human Polyclonal (aa521-534) Antibody
Xenopus, Bat, Rat, Hamster, Horse, Rabbit, Mouse, Dog, Bovine, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ZEB2 / SIP-1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ZEB2 mouse monoclonal antibody.
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ZEB2 / SIP-1 Mouse anti-Human Monoclonal (OTI15G8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ZEB2 / SIP-1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ZEB2 mouse monoclonal antibody.
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ZEB2 / SIP-1 Mouse anti-Human Monoclonal (aa1-350) (Carrier-free) (OTI15G8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ZEB2 / SIP-1 Antibody - ZEB2 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The ZEB2 antibody detected the ZEB2 protein (arrow).
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1078-1105) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa30-79) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ZEB2 / SIP-1 Antibody - Human Fetal Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa52-101) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
ZEB2 / SIP-1 Antibody - 1:100 staining human liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Zebrafish, Rabbit, Mouse, Bovine, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ZEB2 / SIP-1 Antibody - Anti-ZEB2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ZEB2 / SIP-1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa750-800) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$460
ZEB2 / SIP-1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ZEB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB2 / SIP-1 Mouse anti-Human Monoclonal (aa1-350) (OTI1E12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ZEB2 / SIP-1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-ZEB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB2 / SIP-1 Mouse anti-Human Monoclonal (aa1-350) (Carrier-free) (OTI1E12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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ZEB2 / SIP-1 Rabbit Recombinant Monoclonal Antibody
IF, IHC, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
ZEB2 / SIP-1 Antibody - Western blot of SIP1 antibody
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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ZEB2 / SIP-1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$341; 200 µl/$396; 500 µl/$582; 1 ml/$715; 2 ml/$952; 5 ml/$1,625
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1078-1105) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1078-1105) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1078-1105) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1078-1105) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
ZEB2 / SIP-1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using ZEB2 antibody.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ZEB2 / SIP-1 Antibody - Detection of Human SIP1 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-SIP1 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1164-1214) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ZEB2 / SIP-1 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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ZEB2 / SIP-1 Rabbit anti-Human Polyclonal (aa1050-1214) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).