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ZEB1 / AREB6

zinc finger E-box binding homeobox 1

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene Name: zinc finger E-box binding homeobox 1
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: ZEB1, AREB6, BZP, FECD6, NIL-2-A zinc finger protein, TCF-8, Negative regulator of IL2, NIL2A, ZEB, ZFHEP, DELTAEF1, NIL-2-A, PPCD3, TCF8, Transcription factor 8, ZFHX1A
Target Sequences: NM_030751 NP_110378.3 P37275

Publications (3)

1
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C31478.
2
Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives. Federico Armando, Francesco Godizzi, Elisabetta Razzuoli, Fabio Leonardi, Mario Angelone, Attilio Corradi, Daniela Meloni, Luca Ferrari, Benedetta Passeri. Animals: an open access journal from MDPI. 2020 December;10: [Full Text Article] [PubMed:33297475] [PMC:PMC7762370] Related Antibodies: LS-C31478.
3
Investigation of the Epithelial to Mesenchymal Transition (EMT) Process in Equine Papillomavirus-2 (EcPV-2)-Positive Penile Squamous Cell Carcinomas. Federico Armando, Samanta Mecocci, Virginia Orlandi, Ilaria Porcellato, Katia Cappelli , Luca Mechelli, Chiara Brachelente, Marco Pepe , Rodolfo Gialletti , Alessandro Ghelardi, Benedetta Passeri, Elisabetta Razzuoli. International journal of molecular sciences. 2021 Sep;22:10588. [Full Text Article] [PubMed:34638929] [PMC:PMC8508821] Related Antibodies: LS-C31478.

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Antibodies (60)
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ZEB1 / AREB6 (71)
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa23-72) Antibody
WB
Unconjugated
100 µl/$397
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa23-72) (Biotin) Antibody
Zebrafish, Pig, Rabbit, Dog, Bovine, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
ZEB1 / AREB6 Antibody - Immunohistochemistry of paraffin-embedded human stomach cancer using ZEB1 antibody at dilution of 1:100 (400x lens).
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ZEB1 / AREB6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
124.5 kDa
20 µg/$215
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded cervical cancer tissues using ZEB1 mouse monoclonal antibody with DAB staining.
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa967-1108) (2A8A6) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
ZEB1 / AREB6 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ZEB1 / AREB6 Antibody - ZEB1 / AREB6 antibody (0.05µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
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ZEB1 / AREB6 Goat anti-Human Polyclonal (aa326-340) Antibody
Mouse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ZEB1 / AREB6 Antibody - Detection of Human ZEB1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ZEB1 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa1074-1124) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ZEB1 / AREB6 Antibody - Immunohistochemistry of ZEB1 in human liver tissue with ZEB1 antibody at 5 µg/mL.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
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ZEB1 / AREB6 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
50 µg/$558
ZEB1 / AREB6 Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ZEB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa1-350) (OTI3G6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ZEB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa1-350) (Carrier-free) (OTI3G6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded cervical cancer tissues using ZEB1 mouse monoclonal antibody with DAB staining.
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa967-1108) (2A8H3) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
ZEB1 / AREB6 Antibody - Immunohistochemistry: ZEB1 Antibody (2A8A6) - IHC analysis of paraffin-embedded human cervical cancer tissues with DAB staining.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa800-1124) (2A8A6) Antibody
Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
ZEB1 / AREB6 Antibody - Human Small Intestine, MALT: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa850-900) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
ZEB1 / AREB6 Antibody - ZEB1 antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa108-157) Antibody
Human
WB
Unconjugated
100 µl/$424
ZEB1 / AREB6 Antibody - ZEB1 antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa108-157) (Biotin) Antibody
Chicken, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
ZEB1 / AREB6 Antibody - ZEB1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Zebrafish, Pig, Rabbit, Dog, Bovine, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
ZEB1 / AREB6 Antibody - Immunohistochemistry of paraffin-embedded Rat ovary using ZEB1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ZEB1 / AREB6 Antibody - Immunofluorescence of monoclonal antibody to ZEB1 on HeLa cell . [antibody concentration 10 ug/ml]
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (4C4) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded Human lung tissue using anti-ZEB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa1-350) (OTI7E12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ZEB1 / AREB6 Antibody - IHC of paraffin-embedded Human lung tissue using anti-ZEB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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ZEB1 / AREB6 Mouse anti-Human Monoclonal (aa1-350) (Carrier-free) (OTI7E12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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ZEB1 / AREB6 Rabbit anti-Human Polyclonal (aa391-739) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
Viewing 1-25 of 71 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).