ZC3HC1 / NIPA

zinc finger, C3HC-type containing 1

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

ZC3HC1 / NIPA (4)

Publications

No (4)

Tag

GST (2)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human ZC3HC1 / NIPA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90413

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.1 kDa

Price:

20 µg/$150

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Human ZC3HC1 / NIPA Protein (Recombinant GST) (Full Length) - LS-G33803

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ZC3HC1 / NIPA Protein (Recombinant GST) (Full Length) - LS-G33805

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

31.35 kDa

Price:

10 µg/$479; 25 µg/$670

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ZC3HC1 / NIPA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112647

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.1 kDa

Price:

100 µg/$494

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