ZBTB33 / Kaiso

zinc finger and BTB domain containing 33

ZBTB33 / Kaiso is a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

ZBTB33 / Kaiso (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ZBTB33 / Kaiso Protein (Recombinant GST, N-terminus) (aa564-673) - LS-G61321

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ZBTB33 / Kaiso Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88490

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.9 kDa

Price:

20 µg/$215

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Human ZBTB33 / Kaiso Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88491

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$150

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Human ZBTB33 / Kaiso Protein (Recombinant GST) (Full Length) - LS-G31897

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

101 kDa

Price:

2 µg/$439

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ZBTB33 / Kaiso Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130150

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.9 kDa

Price:

100 µg/$710

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ZBTB33 / Kaiso Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115086

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

100 µg/$494

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