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ZBED1 / TRAMP is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
Gene Name: | zinc finger, BED-type containing 1 |
Synonyms: | ZBED1, Ac-like transposable element, ALTE, DREF homolog, HDREF, DREF, KIAA0785, TRAMP |
Target Sequences: | NM_004729 NP_004720.1 O96006 |
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