YY1

YY1 transcription factor

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).

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ELISA Kits (4)

Type

Custom (2)

Sandwich (2)

Target

YY1 (4)

Reactivity

Human (3)

Mouse (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (3)

Publications

No (4)

Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Human YY1 (Sandwich ELISA) ELISA Kit - LS-F50061

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.8 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$672

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Human YY1 (Custom) ELISA Kit - LS-F66259

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

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Mouse YY1 (Custom) ELISA Kit - LS-F65829

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Human YY1 (Sandwich ELISA) ELISA Kit - LS-F8949

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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