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YTHDF2

YTH domain family, member 2

YTHDF2 is a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene Name: YTH domain family, member 2
Synonyms: YTHDF2, CLL-associated antigen KW-14, HGRG8, YTH domain family, member 2, NY-REN-2, YTH domain family 2, YTH domain family protein 2
Target Sequences: NM_016258 NP_057342.2 Q9Y5A9

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
YTHDF2 (3)
No (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
YTHDF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.2 kDa
100 µg/$494
YTHDF2 Protein - 12.5% SDS-PAGE of human YTHDF2 stained with Coomassie Blue
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Wheat Germ Extract
GST
88.7 kDa
2 µg/$439
YTHDF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.2 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).