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YOD1

YOD1 deubiquitinase

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.

Gene Name: YOD1 deubiquitinase
Synonyms: YOD1, DUBA8, DUBA-8, HIN-7, HsHIN7, OTU domain containing 2, OTUD2, PRO0907, RP11-164O23.1, HIN7, HIV-1-induced protease 7, Ubiquitin thioesterase OTU1
Target Sequences: Q5VVQ6 Q5VVQ6

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).