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Yo / CDR2

cerebellar degeneration-related protein 2, 62kDa

Paraneoplastic cerebellar degeneration is a disorder of the cerebellum found in association with neoplasms of lung, ovary, breast, or Hodgkin's disease. Affected brains show extensive loss of Purkinje cells, variable loss of granule and basket neurons and proliferation of Bergman glia. These patients have a circulating antibody called anti-Yo. One of the proteins recognized by Yo is CDR2. CDR2 suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by and unknown mechanism.

Gene Name: cerebellar degeneration-related protein 2, 62kDa
Synonyms: CDR2, CDR62, Yo paraneoplastic antigen, PCD17, Yo
Target Sequences: M63256 AAA51961.1 Q01850

Publications (1)

1
CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration. Torbjørn Kråkenes, Ida Herdlevaer, Margrethe Raspotnig, Mette Haugen, Manja Schubert, Christian A Vedeler. Annals of neurology. 2019 August;86:316-321. [Full Text Article] [PubMed:31148214]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).