YAP / YAP1

Yes-associated protein 1

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

☰ Filters

Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

YAP / YAP1 (9)

Publications

No (9)

Tag

6His, N-terminus (1)

6His-B2M, N-terminus (1)

GST, N-terminus (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (2)

Select

Human YAP / YAP1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23194

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

56.4 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Human YAP / YAP1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G32131

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

80.9 kDa

Price:

10 µg/$479; 25 µg/$670

Select

YAP / YAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100726

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.6 kDa

Price:

100 µg/$710

Select

Human YAP / YAP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64800

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

20 µg/$1,107

Select

Human YAP / YAP1 Protein (Recombinant 6His-B2M, N-terminus) (Full Length) - LS-G137144

Source:

E. coli

Tag:

6His-B2M, N-terminus

Molecular Weight:

68.5 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human YAP / YAP1 Protein (Recombinant GST, N-terminus) (aa53-161) - LS-G61499

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

YAP / YAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130989

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.2 kDa

Price:

100 µg/$494

Select

Human YAP / YAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74230

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.6 kDa

Price:

20 µg/$215

Select

Human YAP / YAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74229

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.2 kDa

Price:

20 µg/$150

Viewing 1-9 of 9 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.