YAP / YAP1

Yes-associated protein 1

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

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Products

ELISA Kits (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (2)

Sandwich (3)

Target

YAP / YAP1 (7)

Reactivity

Human (3)

Mouse (4)

Rat (3)

Chicken (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (5)

Publications

No (6)

Yes (1)

Sample Type

Adherent Cell Cultures (2)

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

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Human YAP / YAP1 (Sandwich ELISA) ELISA Kit - LS-F49700

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Mouse/Human/Rat YAP / YAP1 (Cell-Based ELISA) ELISA Kit - LS-F2396

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Rat YAP / YAP1 (Sandwich ELISA) ELISA Kit - LS-F49374

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-YAP / YAP1 (Ser127) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1281

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse YAP / YAP1 (Sandwich ELISA) ELISA Kit - LS-F9264

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$854

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Chicken YAP / YAP1 (Custom ELISA) ELISA Kit - LS-F49369

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse YAP / YAP1 (Custom ELISA) ELISA Kit - LS-F49370

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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