XRCC5 / Ku80

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

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Products

ELISA Kits (6)

Type

Cell-Based (2)

Cell-Based Phosphorylation (1)

Development Kit (1)

Sandwich (2)

Target

XRCC5 / Ku80 (6)

Reactivity

Human (5)

Mouse (1)

Product Group

DevKit DuoPlus (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (2)

Antibody Pair and Standard (1)

Publications

No (6)

Sample Type

Adherent Cell Cultures (3)

Tissue Homogenates (3)

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Human XRCC5 / Ku80 (Sandwich ELISA) ELISA Kit - LS-F9057

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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DevKit DuoPlus Human XRCC5 / Ku80 ELISA Development Kit - LS-F71506

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

500 Wells/$1,120; 1000 Wells/$1,642

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Human XRCC5 / Ku80 (Cell-Based ELISA) ELISA Kit - LS-F2988

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human Phospho-XRCC5 / Ku80 (Thr714) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1151

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human XRCC5 / Ku80 (Cell-Based ELISA) ELISA Kit - LS-F2114

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse XRCC5 / Ku80 (Sandwich ELISA) ELISA Kit - LS-F9058

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$854

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