XPO5 / Exportin 5

exportin 5

Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

XPO5 / Exportin 5 (5)

Publications

No (5)

Tag

GST (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human XPO5 / Exportin 5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67826

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

136.1 kDa

Price:

20 µg/$1,107

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Human XPO5 / Exportin 5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80791

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

136.3 kDa

Price:

20 µg/$150

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Human XPO5 / Exportin 5 Protein (Recombinant GST) (Full Length) - LS-G34734

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.54 kDa

Price:

10 µg/$479; 25 µg/$670

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Human XPO5 / Exportin 5 Protein (Recombinant His-T7, N-terminus) (Ala2-Gln180) - LS-G133425

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

24.6kDa

Price:

10 µg/$268; 50 µg/$362; 200 µg/$722; 100 µg/$577; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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XPO5 / Exportin 5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111058

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

136.3 kDa

Price:

100 µg/$494

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