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XPO5 / Exportin 5

exportin 5

Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.

Gene Name: exportin 5
Synonyms: XPO5, Exportin 5, Exportin-5, Ran-binding protein 21, Exp5, KIAA1291, RANBP21
Target Sequences: NM_020750 NP_065801.1 Q9HAV4

Filtered By: None
Target
XPO5 / Exportin 5 (32)
Reactivity
Human (32)
Mouse (15)
Rat (15)
Bat (4)
Bovine (5)
Chimpanzee (6)
Dog (1)
Gibbon (9)
Guinea pig (8)
Horse (9)
Monkey (4)
Pig (1)
Rabbit (4)
Application
IHC (11)
IHC-P (3)
WB (32)
ELISA (7)
ICC (1)
IF (3)
IP (2)
Host
rabbit (32)
Isotype
IgG (12)
Clonality
polyclonal pc (32)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (10)
Epitope
aa1123-1152 (8)
aa1115-1164 (4)
aa182-231 (4)
aa190-239 (4)
aa1154-1204 (1)
Publications
No (32)
Showing 1-25 of 32 results

XPO5 / Exportin 5 Antibody IHC-plus™ LS-B14754
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Mouse, Rat, Human
IF IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

XPO5 / Exportin 5 Antibody (aa1154-1204) IHC-plus™ LS-B14196
Rabbit Polyclonal to Human XPO5 / Exportin 5
Mouse, Dog, Bovine, Rat, Pig, Horse, Human
IF IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $425.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Detection of Human Exportin-5 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Exportin-5 antibody used for IP at 6 ug/mg lysate. Exportin-5 was also immunoprecipitated by rabbit anti-Exportin-5 antibody BL14303. For blotting immunoprecipitated Exportin-5, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Detection of Human Exportin-5 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Exportin-5 antibody used for IP at 6 ug/mg lysate. Exportin-5 was also immunoprecipitated by rabbit anti-Exportin-5 antibody BL14303. For blotting immunoprecipitated Exportin-5, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

XPO5 / Exportin 5 Antibody LS-C482711
Rabbit Polyclonal to Human XPO5 / Exportin 5
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Immunohistochemical analysis of Exportin 5 staining in human ovarian cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Exportin 5 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Immunohistochemical analysis of Exportin 5 staining in human ovarian cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Exportin 5 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.

XPO5 / Exportin 5 Antibody (aa182-231) LS-C81104
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Mouse, Guinea pig, Rat, Horse, Human
WB
Unconjugated
50µg  $365.00
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO5 / Exportin 5 Antibody (aa182-231, HRP) LS-C450278
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Mouse, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO5 / Exportin 5 Antibody (aa182-231, Biotin) LS-C450276
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Mouse, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO5 / Exportin 5 Antibody LS-C663489
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (HRP) LS-C713277
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (Biotin) LS-C688476
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (FITC) LS-C695454
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (Cy3) LS-C704258
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (APC, Cy7) LS-C736257
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (PE) LS-C727343
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (APC) LS-C741452
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded brain tissue
Western Blot; Sample: Recombinant protein.

XPO5 / Exportin 5 Antibody (aa1123-1152) LS-C330303
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
Unconjugated
200µl  $530.00

XPO5 / Exportin 5 Antibody (aa1123-1152, Biotin) LS-C273725
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

XPO5 / Exportin 5 Antibody (aa1123-1152, FITC) LS-C273726
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
FITC Conjugated
200µl  $680.00

XPO5 / Exportin 5 Antibody (aa1123-1152, APC) LS-C273724
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
APC Conjugated
200µl  $680.00

XPO5 / Exportin 5 Antibody (aa1123-1152, Azide-free, HRP) LS-C273727
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

XPO5 / Exportin 5 Antibody (aa1123-1152, PE) LS-C273728
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
PE Conjugated
200µl  $680.00

XPO5 / Exportin 5 Antibody (aa1123-1152, AP) LS-C273723
Rabbit Polyclonal (IgG) to Human XPO5 / Exportin 5
Human
ELISA WB
AP Conjugated
200µl  $680.00

XPO5 / Exportin 5 Antibody LS-C662174
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
WB
Unconjugated
100µg  $325.00

XPO5 / Exportin 5 Antibody (aa1115-1164) LS-C111151
Rabbit Polyclonal to Human XPO5 / Exportin 5
Rabbit, Mouse, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
XPO5 / Exportin-5 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
XPO5 / Exportin-5 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO5 / Exportin 5 Antibody (aa1115-1164, Biotin) LS-C450279
Rabbit Polyclonal to Human XPO5 / Exportin 5
Rabbit, Mouse, Guinea pig, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
XPO5 / Exportin-5 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
XPO5 / Exportin-5 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO5 / Exportin 5 Antibody (aa1123-1152) LS-C160667
Rabbit Polyclonal to Human XPO5 / Exportin 5
Human
WB
Unconjugated
400µl  $305.00
XPO5 Antibody western blot of human placenta tissue lysates (35 ug/lane). The XPO5 antibody detected the XPO5 protein (arrow).
XPO5 Antibody western blot of human placenta tissue lysates (35 ug/lane). The XPO5 antibody detected the XPO5 protein (arrow).
Showing 1-25 of 32 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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