XIAP

X-linked inhibitor of apoptosis

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

XIAP (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-S (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human XIAP Protein (Recombinant His, N-Terminal) (aa1-497) - LS-G24983

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

60.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human XIAP Protein (Recombinant) (Leu121-Thr356) - LS-G138078

Source:

E. coli

Tag:

None

Molecular Weight:

29.1 kDa

Price:

100 µg/$721

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XIAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118744

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

100 µg/$494

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Mouse XIAP Protein (Recombinant His-S) (aa8-219) - LS-G24984

Source:

E. coli

Tag:

His-S

Molecular Weight:

27.4 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human XIAP Protein (Recombinant His-SUMO) (Full Length) - LS-G21327

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

72.65 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human XIAP Protein (Recombinant 6His, N-terminus) (Thr2-Ser497) - LS-G26589

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

58.8 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

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Human XIAP Protein (Recombinant GST, N-terminus) (aa51-150) - LS-G57783

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human XIAP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67347

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

20 µg/$1,107

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Human XIAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79607

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

20 µg/$150

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