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XDH / Xanthine Oxidase

xanthine dehydrogenase

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

Gene Name:	xanthine dehydrogenase
Synonyms:	XDH, Xanthene dehydrogenase, XOR, Xanthine dehydrogenase/oxidase, Xanthine oxidase, XO, Xanthine dehydrogenase, Xanthine oxidoreductase, XDHA
Target Sequences:	NM_000379 NP_000370.2 P47989

Publications (3)

Aging enhances pressure-induced arterial superoxide formation. Jacobson A, Yan C, Gao Q, Rincon-Skinner T, Rivera A, Edwards J, Huang A, Kaley G, Sun D. American journal of physiology. Heart and circulatory physiology. 2007 293:H1344-50. [PubMed:17557915]

Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells. Papi A, Contoli M, Gasparini P, Bristot L, Edwards MR, Chicca M, Leis M, Ciaccia A, Caramori G, Johnston SL, Pinamonti S. The Journal of biological chemistry. 2008 283:28595-606. (WB; Human) [Full Text Article] [PubMed:18678861] [PMC:PMC2661410]

Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. Masao Sakabe, Akira Fujiki, Tamotsu Sakamoto, Yosuke Nakatani, Koichi Mizumaki, Hiroshi Inoue. Journal of cardiovascular electrophysiology. 2012 October;23:1130-5. [Full Text Article] [PubMed:22587612] Related Antibodies: LS-C59315.

Xanthine Oxidase Assay Kit (Colorimetric/Fluorometric) - LS-K201

Type:

Detection/Quantition

Target:

XDH / Xanthine Oxidase

Application:

Spectrophotometry (fluorometric), Spectrophotometry (visible)

Price:

100 Tests/$450

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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