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XCL1 / Lymphotactin

chemokine (C motif) ligand 1

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.

Gene Name: chemokine (C motif) ligand 1
Family/Subfamily: Intercrine , Intercrine gamma
Synonyms: XCL1, ATAC, C motif chemokine 1, Chemokine (C motif) ligand 1, Cytokine SCM-1, Cytokine scm, LPTN, SCM-1, SCM-1-alpha, SCM-1a, SCM1, SCYC1, Scyc2, Single cysteine motif 1a, Lymphotaxin, Xc chemokine ligand, LTN, Lymphotactin, SCM1A, Small-inducible cytokine C1, XC chemokine ligand 1
Target Sequences: NM_002995 NP_002986.1 P47992

Publications (3)

1
Targeting Influenza Virus Hemagglutinin to Xcr1+<sup> Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. Gudjonsson A, Lysén A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B, Fossum E. Journal of immunology (Baltimore, Md. : 1950). 2017 April;198:2785-2795. [Full Text Article] [PubMed:28228559]
2
Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes. Agata Ciechanowska, Katarzyna Popiolek-Barczyk, Katarzyna Ciapala, Katarzyna Pawlik, Marco Oggioni, Domenico Mercurio, Maria-Grazia de Simoni, Joanna Mika. Pharmacological reports : PR. 2020 December;72:1579-1592. [Full Text Article] [PubMed:33185818] [PMC:PMC7704520]
3
A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza. Ranveig Braathen, Heidi Cecilie Larsen Spång, Daniëla Maria Hinke, Jana Blazevski, Sonja Bobic, Even Fossum, Bjarne Bogen. Molecular Therapy Methods & Clinical Development. 2020 Jan;17:378-392. [Full Text Article] [PubMed:32128342] [PMC:PMC7044496]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).