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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XBP1

X-box binding protein 1

XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Gene Name: X-box binding protein 1
Synonyms: XBP1, X-box binding protein 1, X-box-binding protein 1, XBP2, TREB5, XBP-1
Target Sequences: NM_005080 NP_005071.2 P17861

Publications (4)

1
2-Methoxyestradiol at low dose induces differentiation of myeloma cells. Hou J, Xiong H, Gao W, Jiang H. Leukemia research. 2005 29:1059-67. [PubMed:16038732]
2
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC. Circulation research. 2006 99:275-82. [PubMed:16794188]
3
Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol. Zhou X, Jiang H, Hou J. Leukemia research. 2007 31:1259-65. [PubMed:17257674]
4
Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Kim KM, Pae HO, Zheng M, Park R, Kim YM, Chung HT. Circulation research. 2007 101:919-27. [PubMed:17823375]
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Viewing 1-25 of 67 items
XBP1 Antibody - Anti-XBP1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 9B7E5] (IgG1,k) to Human XBP1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
XBP1 Antibody - Anti-XBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
XBP1 Antibody - Anti-XBP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
XBP1 Antibody - Anti-XBP1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human XBP1
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
XBP1 Antibody - Anti-XBP1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal [clone 3H1G4] (IgG1) to Human XBP1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
XBP1 Antibody - Anti-XBP1 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal to Human XBP1
Human
Flo, IHC, IHC-P, WB
Unconjugated
200µl   $425.00
XBP1 Antibody - Anti-XBP1 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 2D9] (IgG2a,k) to Human XBP1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Human
ELISA, ICC, WB
Unconjugated
100µg   $530.00
XBP1 Antibody - XBP antibody IHC-paraffin. IHC(P): Mouse Lung Tissue.
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Rabbit Polyclonal to Human XBP1
Mouse, Rat, Hamster, Human
IHC, IHC-P, WB
Unconjugated
100µg   $325.00
XBP1 Antibody - XBP1 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The XBP1 antibody detected the XBP1 protein (arrow).
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Rabbit Polyclonal to Human XBP1
Mouse, Human
WB
Unconjugated
400µl   $325.00
XBP1 Antibody - Immunofluorescence analysis of U2OS cells using XBP1 antibodyat dilution of 1:100. Blue: DAPI for nuclear staining.
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Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
Select
Mouse Monoclonal (IgG1) to Human XBP1
Human
Flo
Unconjugated
100µg   $650.00
XBP1 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human XBP1
Rabbit, Bovine, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
XBP1 Antibody - Lane A: Marker. Lane B: Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human XBP1
Rabbit, Dog, Bovine, Pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   $740.00
XBP1 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using XBP1 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human XBP1
Human
ELISA, IF, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00
XBP1 Antibody - Immunohistochemistry of paraffin-embedded human uterus using XBP1 antibody at dilution of 1:100 (40x lens).
Select
Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
XBP1 Antibody
Select
Rabbit Polyclonal (IgG) to Human XBP1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
XBP1 Antibody - Immunofluorescence analysis of U2OS cells using XBP1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Select
Rabbit Polyclonal (IgG) to Human XBP1
Rat, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00

Viewing 1-25 of 67 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).