XAF1

XIAP associated factor 1

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

XAF1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human XAF1 Protein (Recombinant GST, N-terminus) (aa202-301) - LS-G62615

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human XAF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85510

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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Human XAF1 Protein (Recombinant GST) (Full Length) - LS-G34041

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61 kDa

Price:

10 µg/$479; 25 µg/$670

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Human XAF1 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144818

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

62.4 kDa

Price:

50 µg/$419

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Human XAF1 Protein (Recombinant His) - LS-G2892

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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XAF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101479

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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