XAF1

XIAP associated factor 1

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

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Products

Antibodies (30)

Proteins (6)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (30)

Recombinant (4)

Sandwich (1)

Target

XAF1 (37)

Reactivity

Human (23)

Mouse (12)

Rat (3)

Chimpanzee (6)

Gibbon (3)

Monkey (4)

Application

IHC (8)

IHC-P (6)

WB (25)

ELISA (12)

IF (4)

IP (1)

Peptide-ELISA (1)

Host

rabbit (30)

Product Group

IHCPlus (2)

Isotype

IgG (26)

Clonality

polyclonal pc (30)

Format

96-Well Strip Plate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Sepharose Conjugated (1)

Unconjugated (15)

Epitope

aa166-194 (7)

aa107-156 (4)

aa215-264 (4)

C-Terminus (3)

aa283-301 (2)

aa201-218 (1)

aa235-269 (1)

Publications

No (36)

Yes (1)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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IHC-plus™ XAF1 Antibody LS-B618

(4.0) Rating

Antibody:

XAF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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XAF1 Antibody (aa166-194) LS-C158287

(4.0) Rating

(1) Publication(s)

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ XAF1 Antibody LS-B1436

(4.0) Rating

Antibody:

XAF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$440

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XAF1 Antibody (aa235-269) LS-C344274

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa235-269) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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XAF1 Antibody LS-C501165

Antibody:

XAF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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XAF1 Antibody (HRP) LS-C501167

Antibody:

XAF1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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XAF1 Antibody (Biotin) LS-C501187

Antibody:

XAF1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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XAF1 Antibody (FITC) LS-C501168

Antibody:

XAF1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

XAF1 Antibody (C-Terminus) LS-C122554

Antibody:

XAF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

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XAF1 Antibody (aa283-301) LS-C122231

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa283-301) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$723

Select

XAF1 Antibody (C-Terminus) LS-C172000

Antibody:

XAF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

Select

XAF1 Antibody (aa283-301) LS-C389407

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa283-301) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

XAF1 Antibody (aa166-194) LS-C326382

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

XAF1 Antibody (aa166-194, Biotin) LS-C273663

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

XAF1 Antibody (aa166-194, FITC) LS-C273664

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

XAF1 Antibody (aa166-194, APC) LS-C273661

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

XAF1 Antibody (aa166-194, Azide-free, HRP) LS-C273665

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

XAF1 Antibody (aa166-194, PE) LS-C273666

Antibody:

XAF1 Rabbit anti-Mouse Polyclonal (aa166-194) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

XAF1 Antibody (aa201-218) LS-C842

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa201-218) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$386

Select

XAF1 Antibody LS-C803819

Antibody:

XAF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

XAF1 Antibody LS-C746660

Antibody:

XAF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$425

Select

XAF1 Antibody (aa107-156) LS-C107929

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa107-156) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

XAF1 Antibody (aa107-156, Biotin) LS-C462753

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa107-156) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

XAF1 Antibody (aa107-156, FITC) LS-C462754

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa107-156) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

Select

XAF1 Antibody (aa215-264) LS-C108080

Antibody:

XAF1 Rabbit anti-Human Polyclonal (aa215-264) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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