WWTR1 / TAZ

WW domain containing transcription regulator 1

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

☰ Filters

Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

WWTR1 / TAZ (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Select

Human WWTR1 / TAZ Protein (Recombinant His) - LS-G2695

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

Human WWTR1 / TAZ Protein (Recombinant GST, N-terminus) (aa201-300) - LS-G62113

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human WWTR1 / TAZ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91394

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.6 kDa

Price:

20 µg/$150

Select

Human WWTR1 / TAZ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91396

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$150

Select

Human WWTR1 / TAZ Protein (Recombinant GST) (Full Length) - LS-G33034

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.5 kDa

Price:

10 µg/$479; 25 µg/$670

Select

WWTR1 / TAZ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129738

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.6 kDa

Price:

100 µg/$494

Select

Human WWTR1 / TAZ Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72094

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$1,107

Select

WWTR1 / TAZ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113194

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

100 µg/$494

Viewing 1-8 of 8 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.