WTIP

Wilms tumor 1 interacting protein

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture By similarity. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

WTIP (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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Human WTIP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73492

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.9 kDa

Price:

20 µg/$1,107

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Human WTIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G95391

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.9 kDa

Price:

20 µg/$215

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WTIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120222

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.9 kDa

Price:

100 µg/$710

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