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WTAP
Wilms tumor 1 associated protein
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
| Gene Name: | Wilms tumor 1 associated protein |
| Synonyms: | WTAP, HFL(2)D, KIAA0105, PNAS-132, WT1-associated protein, Female-lethal(2)D homolog |
| Target Sequences: | NM_004906 NP_004897.2 Q15007 |
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