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WT1 / Wilms Tumor 1

Wilms tumor 1

WT1 / Wilms Tumor 1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Gene Name: Wilms tumor 1
Synonyms: WT1, GUD, EWS-WT1, Amino-terminal domain of EWS, WAGR, WIT-2, Wilms tumor protein, AWT1, Wilms tumor 1, WT33, NPHS4, WT-1
Target Sequences: NM_024426 NP_077744.3 P19544

Publications (5)

1
Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. Rauscher FJ, Morris JF, Fredericks WJ, Lopez-Guisa J, Balakrishnan C, Jost M, Herlyn M, Rodeck U. Hybridoma. 1998 17:191-8. [PubMed:9627060]
2
WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia. McCarty G, Awad O, Loeb DM. The Journal of biological chemistry. 2011 286:43634-43. [PubMed:22030397] [PMC:PMC3243556]
3
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Musah S, , Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, , Ingber DE, ,. Nature biomedical engineering. 2017 1: (IHC; Human) [Full Text Article] [PubMed:29038743] Related Antibodies: LS-C224662.
4
Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective. Hodgin JB, Bitzer M, Wickman L, Afshinnia F, Wang SQ, O'Connor C, Yang Y, Meadowbrooke C, Chowdhury M, Kikuchi M, Wiggins JE, Wiggins RC. Journal of the American Society of Nephrology : JASN. 2015 26:3162-78. (WB; Human) [Full Text Article] [PubMed:26038526]
5
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Samira Musah, Nikolaos Dimitrakakis, Diogo M Camacho, George M Church, Donald E Ingber. Nature protocols. 2018 Jul;13:1662-1685. [Full Text Article] [PubMed:29995874] [PMC:PMC6701189] Related Antibodies: LS-C224662.
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ELISA Kits (7)
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WT1 / Wilms Tumor 1 (7)
Human (4)
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Pig (1)
96-Well Strip Plate (7)
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Cell Lysates (1)
Plasma (3)
Serum (3)
Tissue Homogenates (3)
WT1 / Wilms Tumor 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
WT1 / Wilms Tumor 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
WT1 / Wilms Tumor 1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
WT1 / Wilms Tumor 1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
WT1 / Wilms Tumor 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
WT1 / Wilms Tumor 1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$968
WT1 / Wilms Tumor 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).