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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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WRNIP1 / WHIP

Werner helicase interacting protein 1

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Gene Name: Werner helicase interacting protein 1
Synonyms: WRNIP1, Putative helicase RUVBL, WHIP, RP11-420G6.2, ATPase WRNIP1, BA420G6.2
Target Sequences: NM_020135 NP_064520.2 Q96S55

Filtered by: None
Target
WRNIP1 / WHIP (19)
Reactivity
Human (19)
Mouse (7)
Rat (6)
Bat (5)
Bovine (4)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Hamster (5)
Horse (1)
Monkey (6)
Pig (1)
Application
IHC (7)
IHC-P (6)
WB (17)
ELISA (8)
IF (1)
IP (1)
Peptide-ELISA (1)
Host
rabbit (18)
goat (1)
Isotype
IgG (12)
Clonality
polyclonal pc (19)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (10)
Epitope
aa1-30 (8)
aa67-116 (4)
aa400-450 (2)
Internal (1)
aa652-665 (1)
Publications
No (19)
Showing 1-19 of 19 results

IHC-plus™ WRNIP1 / WHIP Antibody (aa67-116) LS-B683
Rabbit Polyclonal to Human WRNIP1 / WHIP
Mouse, Bovine, Rat, Hamster, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-WRNIP1 / WHIP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-WRNIP1 / WHIP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

WRNIP1 / WHIP Antibody (aa67-116, HRP) LS-C434297
Rabbit Polyclonal to Human WRNIP1 / WHIP
Mouse, Bovine, Rat, Hamster, Bat, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-WRNIP1 / WHIP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-WRNIP1 / WHIP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

WRNIP1 / WHIP Antibody (aa67-116, Biotin) LS-C434294
Rabbit Polyclonal to Human WRNIP1 / WHIP
Mouse, Bovine, Rat, Hamster, Bat, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-WRNIP1 / WHIP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-WRNIP1 / WHIP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

WRNIP1 / WHIP Antibody (aa67-116, FITC) LS-C434296
Rabbit Polyclonal to Human WRNIP1 / WHIP
Mouse, Bovine, Rat, Hamster, Bat, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-WRNIP1 / WHIP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-WRNIP1 / WHIP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ WRNIP1 / WHIP Antibody (Internal) LS-B436
Rabbit Polyclonal to Human WRNIP1 / WHIP
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $485.00
Anti-WRNIP1 / WHIP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Human WHIP Antibody - Western Blot. Western blot analysis is shown using Affinity Purified anti-Human WHIP antibody to detect Human WHIP present in a HEK293 whole cell lysate. ~30 ug of lysate was loaded per lane for 4-20% gradient SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a primary band of ~96.0 kD is detected. The identity of the minor band migrating at a slightly higher molecular weight is unknown, but may represent an alternate isoform of WHIP or post translational modification of the WHIP protein. See Figure 2 for the results of peptide competition experiments. The blot was incubated with a 1:200 dilution of the antibody at room temperature for 2 h followed by detection using IRDye 800 labeled Goat-a-Rabbit IgG [H&L] MX10 ( diluted 1:5000 for 45 min. IRDye 800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.

WRNIP1 / WHIP Antibody (aa400-450) LS-C285946
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Mouse, Human
IF, IHC
Unconjugated
100µl  $415.00
Detection of Human WRNIP1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-WRNIP1 used at a dilution of 1:250.
Detection of Mouse WRNIP1 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-WRNIP1 used at a dilution of 1:250.

WRNIP1 / WHIP Antibody (aa400-450) LS-C288184
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
IHC, IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human WRNIP1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-WRNIP1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

WRNIP1 / WHIP Antibody (aa1-30) LS-C326376
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
Unconjugated
200µl  $590.00

WRNIP1 / WHIP Antibody (aa1-30, Biotin) LS-C242782
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

WRNIP1 / WHIP Antibody (aa1-30, FITC) LS-C242783
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

WRNIP1 / WHIP Antibody (aa1-30, Azide-free, HRP) LS-C247259
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

WRNIP1 / WHIP Antibody (aa1-30, AP) LS-C242780
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
AP Conjugated
200µl  $740.00

WRNIP1 / WHIP Antibody (aa1-30, PE) LS-C242786
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
PE Conjugated
200µl  $740.00

WRNIP1 / WHIP Antibody (aa1-30, APC) LS-C242781
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
ELISA, WB
APC Conjugated
200µl  $740.00

WRNIP1 / WHIP Antibody (aa652-665) LS-C55687
Goat Polyclonal to Human WRNIP1 / WHIP
Mouse, Dog, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
100µg 0.5mg/ml  $405.00
Goat Anti-WHIP / WRNIP1 Antibody (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Goat Anti-WHIP / WRNIP1 Antibody (1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.

WRNIP1 / WHIP Antibody LS-C155277
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
WB
Unconjugated
100µl 0.69mg/ml  $355.00
Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE WRNIP1 / WHIP antibody diluted at 1:1000

WRNIP1 / WHIP Antibody (aa1-30) LS-C157374
Rabbit Polyclonal to Human WRNIP1 / WHIP
Human
WB
Unconjugated
400µl  $325.00
WRNIP1 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The WRNIP1 antibody detected the WRNIP1 protein (arrow).

WRNIP1 / WHIP Antibody LS-C410704
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of HeLa cells.

WRNIP1 / WHIP Antibody LS-C661627
Rabbit Polyclonal (IgG) to Human WRNIP1 / WHIP
Human
Unconjugated
100µg  $435.00
Showing 1-19 of 19 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).