WRN

Werner syndrome, RecQ helicase-like

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

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Products

Antibodies (24)

Type

Primary (24)

Target

WRN (24)

Reactivity

Human (24)

Mouse (3)

Rat (1)

Application

IHC (4)

IHC-P (1)

WB (22)

Flo (2)

ELISA (12)

IF (2)

IP (2)

Peptide-ELISA (3)

Host

rabbit (21)

mouse (3)

Product Group

IHCPlus (1)

Isotype

IgG (17)

IgG1 (1)

IgG1,k (1)

IgG2a (1)

Clonality

monoclonal mc (3)

polyclonal pc (21)

Clone

2F7 (1)

Format

APC Conjugated (1)

Azide-free (2)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (19)

Epitope

aa787-816 (7)

aa1400-C-term (2)

pSer1141 (2)

1080-1160 aa (1)

aa1322-1433 (1)

aa400-450 (1)

Publications

No (24)

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IHC-plus™ WRN Antibody (aa787-816) LS-B13764

(4.0) Rating

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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WRN Antibody LS-C809785

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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WRN Antibody (phospho-Ser1141) LS-C826917

Antibody:

WRN Rabbit anti-Human Polyclonal (pSer1141) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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WRN Antibody LS-C144273

Antibody:

WRN Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$453; 100 µl/$643

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WRN Antibody LS-C409076

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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WRN Antibody (aa1322-1433, Azide-free) LS-C329118

Antibody:

WRN Mouse anti-Human Monoclonal (aa1322-1433) (Azide-free) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated, Azide-free

Price:

100 µg/$705

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WRN Antibody (aa787-816) LS-C326375

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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WRN Antibody (aa787-816, Biotin) LS-C273640

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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WRN Antibody (aa787-816, FITC) LS-C273639

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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WRN Antibody (aa787-816, APC) LS-C273638

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) (APC) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

WRN Antibody (aa787-816, PE) LS-C273642

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

WRN Antibody (aa787-816, Azide-free, HRP) LS-C273641

Antibody:

WRN Rabbit anti-Human Polyclonal (aa787-816) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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WRN Antibody LS-C832732

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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WRN Antibody (clone 2F7) LS-C198442

Antibody:

WRN Mouse anti-Human Monoclonal (2F7) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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WRN Antibody (1080-1160 aa) LS-C380997

Antibody:

WRN Rabbit anti-Human Polyclonal (1080-1160 aa) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

WRN Antibody LS-C661626

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

WRN Antibody LS-C413744

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$394

Select

WRN Antibody (aa400-450) LS-C287155

Antibody:

WRN Rabbit anti-Human Polyclonal (aa400-450) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

WRN Antibody (aa1400-C-term) LS-C287156

Antibody:

WRN Rabbit anti-Human Polyclonal (aa1400-C-term) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$514

Select

WRN Antibody (phospho-Ser1141) LS-C199734

Antibody:

WRN Rabbit anti-Human Polyclonal (pSer1141) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

WRN Antibody (aa1400-C-term) LS-C286637

Antibody:

WRN Rabbit anti-Human Polyclonal (aa1400-C-term) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

WRN Antibody LS-C662388

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

WRN Antibody LS-C668367

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

WRN Antibody LS-C782741

Antibody:

WRN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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