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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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WRN

Werner syndrome, RecQ helicase-like

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Gene Name: Werner syndrome, RecQ helicase-like
Synonyms: WRN, Exonuclease WRN, RecQ protein-like 2, RECQL2, RECQL3, Werner syndrome, RECQ3, DNA helicase, RecQ-like type 3
Target Sequences: NM_000553 NP_000544.2 Q14191

Filtered by: None
Target
WRN (21)
Reactivity
Human (21)
Mouse (2)
Application
IHC (3)
IHC-P (2)
WB (20)
Flo (8)
ELISA (12)
ICC (1)
IF (2)
IP (3)
Peptide-ELISA (1)
Host
rabbit (18)
mouse (3)
Isotype
IgG (14)
IgG1 (1)
IgG1,k (1)
IgG2a (1)
Clonality
monoclonal mc (3)
polyclonal pc (18)
Clone
2F7 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (2)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (15)
Epitope
aa787-816 (8)
C-Terminus (2)
1080-1160 aa (1)
aa1322-1433 (1)
aa400-450 (1)
pSer1141 (1)
Publications
No (21)
Showing 1-21 of 21 results

WRN Antibody (aa787-816) IHC-plus™ LS-B13764
Rabbit Polyclonal to Human WRN
Human
Flo IHC IHC-P WB
Unconjugated
200µl  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
WRN Antibody (Center T802) western blot of K562 cell line lysates (35 ug/lane). The WRN antibody detected the WRN protein (arrow).

WRN Antibody LS-C409076
Rabbit Polyclonal (IgG) to Human WRN
Human
WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cells.

WRN Antibody LS-C144273
Mouse Monoclonal (IgG1) to Human WRN
Mouse, Human
ICC IHC IP WB
Unconjugated
20µl  $395.00; 100µl  $605.00

WRN Antibody (aa1322-1433, Azide-free) LS-C329118
Mouse Monoclonal (IgG2a) to Human WRN
Human
ELISA IF WB
Unconjugated, Azide-free
100µg  $560.00

WRN Antibody (C-Terminus) LS-C286637
Rabbit Polyclonal (IgG) to Human WRN
Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human WRN by Immunohistochemistry. Sample: FFPE section of human seminoma. Antibody: Affinity purified rabbit anti-WRN used at a dilution of 1:250.

WRN Antibody (aa787-816) LS-C326375
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
Unconjugated
200µl  $590.00

WRN Antibody (aa787-816, Biotin) LS-C273640
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
Biotin Conjugated
200µl  $740.00

WRN Antibody (aa787-816, FITC) LS-C273639
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
FITC Conjugated
200µl  $740.00

WRN Antibody (aa787-816, AP) LS-C273637
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
AP Conjugated
200µl  $740.00

WRN Antibody (aa787-816, APC) LS-C273638
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
APC Conjugated
200µl  $740.00

WRN Antibody (aa787-816, Azide-free, HRP) LS-C273641
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
HRP Conjugated, Azide-free
200µl  $740.00

WRN Antibody (aa787-816, PE) LS-C273642
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA Flo WB
PE Conjugated
200µl  $740.00

WRN Antibody (clone 2F7) LS-C198442
Mouse Monoclonal [clone 2F7] (IgG1,k) to Human WRN
Human
ELISA WB
Unconjugated
100µg  $355.00
WRN monoclonal antibody (M06), clone 2F7. Western Blot analysis of WRN expression in Jurkat.

WRN Antibody LS-C661626
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA WB
Unconjugated
100µg  $465.00

WRN Antibody (1080-1160 aa) LS-C380997
Rabbit Polyclonal (IgG) to Human WRN
Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00

WRN Antibody LS-C413744
Rabbit Polyclonal to Human WRN
Mouse, Human
ELISA WB
Unconjugated
100µg 1mg/ml  $345.00

WRN Antibody (C-Terminus) LS-C287156
Rabbit Polyclonal (IgG) to Human WRN
Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

WRN Antibody (aa400-450) LS-C287155
Rabbit Polyclonal (IgG) to Human WRN
Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

WRN Antibody (phospho-Ser1141) LS-C199734
Rabbit Polyclonal (IgG) to Human WRN
Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from K562 cells treated with etoposide 25uM 24h, using Werner Syndrome Helicase (Phospho-Ser1141) Antibody. The lane on the right is blocked with the phospho peptide.

WRN Antibody LS-C662388
Rabbit Polyclonal to Human WRN
Human
WB
Unconjugated
100µg  $325.00
Western blot - Anti-WRN Picoband Antibody

WRN Antibody LS-C668367
Rabbit Polyclonal to Human WRN
Human
WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Western blot Image
Showing 1-21 of 21 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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