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WRAP73 / WDR8 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification.
Gene Name: | WD repeat containing, antisense to TP73 |
Synonyms: | WRAP73, WD repeat domain 8, WD repeat-containing protein 8, WDR8 |
Target Sequences: | NM_017818 NP_060288.3 Q9P2S5 |
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