WNK4

WNK lysine deficient protein kinase 4

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K+ channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

WNK4 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human WNK4 Protein (Recombinant GST, N-terminus) (aa1144-1243) - LS-G63139

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human WNK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72412

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.6 kDa

Price:

20 µg/$1,107

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Human WNK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92283

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.6 kDa

Price:

20 µg/$215

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WNK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108847

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.6 kDa

Price:

100 µg/$710

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