WNK2

WNK lysine deficient protein kinase 2

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

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Products

Antibodies (17)

Type

Primary (17)

Target

WNK2 (17)

Reactivity

Human (17)

Mouse (5)

Rat (3)

Monkey (3)

Orangutan (3)

Application

IHC (3)

IHC-P (4)

WB (12)

ELISA (4)

IF (1)

Peptide-ELISA (1)

Host

rabbit (15)

mouse (2)

Isotype

IgG (7)

IgG1 (1)

IgG1,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (15)

Clone

2E10 (1)

Format

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (11)

Epitope

aa136-185 (4)

Internal (1)

N-Terminus (1)

aa2118-2218 (1)

Publications

No (17)

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WNK2 Antibody (Internal) LS-C353539

Antibody:

WNK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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WNK2 Antibody (clone 2E10) LS-C133809

Antibody:

WNK2 Mouse anti-Human Monoclonal (2E10) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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WNK2 Antibody LS-C807445

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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WNK2 Antibody LS-C674188

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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WNK2 Antibody (HRP) LS-C674190

Antibody:

WNK2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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WNK2 Antibody (Biotin) LS-C674191

Antibody:

WNK2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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WNK2 Antibody (FITC) LS-C674189

Antibody:

WNK2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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WNK2 Antibody (aa2118-2218, Azide-free) LS-C329109

Antibody:

WNK2 Mouse anti-Human Monoclonal (aa2118-2218) (Azide-free) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated, Azide-free

Price:

100 µg/$705

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WNK2 Antibody (N-Terminus) LS-C11067

Antibody:

WNK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$832

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WNK2 Antibody LS-C340923

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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WNK2 Antibody LS-C410125

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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WNK2 Antibody (aa136-185) LS-C151933

Antibody:

WNK2 Rabbit anti-Human Polyclonal (aa136-185) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

WNK2 Antibody (aa136-185, HRP) LS-C472958

Antibody:

WNK2 Rabbit anti-Human Polyclonal (aa136-185) (HRP) Antibody

Reactivity:

Human, Monkey, Orangutan

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

WNK2 Antibody (aa136-185, Biotin) LS-C472956

Antibody:

WNK2 Rabbit anti-Human Polyclonal (aa136-185) (Biotin) Antibody

Reactivity:

Human, Monkey, Orangutan

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

WNK2 Antibody (aa136-185, FITC) LS-C472957

Antibody:

WNK2 Rabbit anti-Human Polyclonal (aa136-185) (FITC) Antibody

Reactivity:

Human, Monkey, Orangutan

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

WNK2 Antibody LS-C412160

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

WNK2 Antibody LS-C780166

Antibody:

WNK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µg/$357

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