WNK1

WNK lysine deficient protein kinase 1

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.

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Products

Proteins (3)

Type

Recombinant (3)

Target

WNK1 (3)

Publications

No (3)

Tag

GST, N-terminus (2)

His-T7 (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (2)

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Human WNK1 Protein (Recombinant GST, N-terminus) (aa296-384) - LS-G63134

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human WNK1 Protein (Recombinant His-T7) (aa1954-2231) - LS-G25807

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human WNK1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G135961

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

73.5 kDa

Price:

10 µg/$479; 25 µg/$670

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