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CCN5

WNT1 inducible signaling pathway protein 2

WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Gene Name: WNT1 inducible signaling pathway protein 2
Synonyms: WISP2, CCN5, CCN family member 5, CTGFL, CT58, CTGF-L, WISP-2
Target Sequences: NM_003881 NP_003872.1 O76076

Publications (2)

1
RNA-sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas. Eddie Luidy Imada, Diego Strianese, Deepak P Edward, Rawan alThaqib, Antionette Price, Antje Arnold, Hailah Al-Hussain, Luigi Marchionni, Fausto J Rodriguez. Brain pathology (Zurich, Switzerland). 2022 January;32:e13007. [Full Text Article] [PubMed:34297428] [PMC:PMC8713532] Related Antibodies: LS-B6392.
2
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction. Sima Zolfaghari, Ole Jørgen Kaasbøll, M Shakil Ahmed, Fabian A Line, Else Marie V Hagelin, Vivi T Monsen, Håvard Attramadal. Journal of cell communication and signaling. 2021 December;16:377-395. [Full Text Article] [PubMed:34854055] [PMC:PMC9411331] Related Antibodies: LS-C349158.

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Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
CCN5 (11)
No (11)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
Myc-DDK (Flag) (3)
Human (7)
Mouse (2)
Rat (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (4)
Low endotoxin level (2)
Biologically active (1)
CCN5 Protein
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E. coli
6His-SUMO, N-terminus
40.5 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CCN5 Protein
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E. coli
His
27.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CCN5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~24.5 kDa
20 µg/$377
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
24.3 kDa
5 µg/$268; 20 µg/$349
CCN5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CCN5 Protein - Purified recombinant protein WISP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
24.2 kDa
20 µg/$1,107
CCN5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.83 kDa
20 µg/$150
CCN5 Protein - Recombinant WNT1 Inducible Signaling Pathway Protein 2 By SDS-PAGE
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E. coli
His
24.3 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
CCN5 Protein - 12.5% SDS-PAGE of human WISP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.71 kDa
10 µg/$479; 25 µg/$670
CCN5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.83 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).