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CCN5

WNT1 inducible signaling pathway protein 2

WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Gene Name: WNT1 inducible signaling pathway protein 2
Synonyms: WISP2, CCN5, CCN family member 5, CTGFL, CT58, CTGF-L, WISP-2
Target Sequences: NM_003881 NP_003872.1 O76076

Publications (2)

1
RNA-sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas. Eddie Luidy Imada, Diego Strianese, Deepak P Edward, Rawan alThaqib, Antionette Price, Antje Arnold, Hailah Al-Hussain, Luigi Marchionni, Fausto J Rodriguez. Brain pathology (Zurich, Switzerland). 2022 January;32:e13007. [Full Text Article] [PubMed:34297428] [PMC:PMC8713532] Related Antibodies: LS-B6392.
2
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction. Sima Zolfaghari, Ole Jørgen Kaasbøll, M Shakil Ahmed, Fabian A Line, Else Marie V Hagelin, Vivi T Monsen, Håvard Attramadal. Journal of cell communication and signaling. 2021 December;16:377-395. [Full Text Article] [PubMed:34854055] [PMC:PMC9411331] Related Antibodies: LS-C349158.

☰ Filters
Antibodies (37)
Proteins (11)
ELISA Kits (6)
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Over-Expression Lysate (2)
Primary (37)
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Sandwich CLIA (1)
CCN5 (54)
Human (32)
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IHC-P (5)
WB (34)
ELISA (11)
IF (1)
Peptide-ELISA (1)
rabbit (36)
mouse (1)
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IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (36)
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APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
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HRP Conjugated (4)
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aa15-250 (8)
aa24-250 (8)
aa87-116 (7)
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6His, N-terminus (1)
6His-SUMO, N-terminus (1)
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Human (7)
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CCN5 Antibody - Anti-WISP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CCN5 Mouse anti-Human Monoclonal (1E11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CCN5 Antibody - Immunohistochemistry of paraffin-embedded human colon carcinoma tissue.
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CCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CCN5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
CCN5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
CCN5 Protein
Select
E. coli
6His-SUMO, N-terminus
40.5 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CCN5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
CCN5 Protein
Select
E. coli
His
27.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CCN5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CCN5 Antibody - Western blot of recombinant WISP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCN5 Rabbit anti-Rat Polyclonal (aa15-250) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
CCN5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~24.5 kDa
20 µg/$377
CCN5 Antibody - WISP2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CCN5 Antibody - Western Blot (non-reducing) of WISP2 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCN5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCN5 Antibody - Western Blot (non-reducing) of WISP2 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCN5 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
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CCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
24.3 kDa
5 µg/$268; 20 µg/$349
CCN5 Antibody - Immunohistochemistry of paraffin-embedded rat brain using WISP2 antibody at dilution of 1:100 (40x lens).
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CCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CCN5 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCN5 Antibody - Immunohistochemistry of paraffin-embedded human testicle using antibody at 1:100 dilution.
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CCN5 Rabbit anti-Human Polyclonal (aa1-250) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CCN5 Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using WISP2 Polyclonal Antibody at dilution of 1:45(×200)
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CCN5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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CCN5 Rabbit anti-Human Polyclonal (aa87-116) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Viewing 1-25 of 54 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).