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WFDC2 / HE4

WAP four-disulfide core domain 2

WFDC2 / HE4 is a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Gene Name: WAP four-disulfide core domain 2
Synonyms: WFDC2, Epididymis-specific he4, Epididymal protein 4, DJ461P17.6, EDDM4, HE4, WAP5
Target Sequences: NM_006103 NP_006094.3 Q14508

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).