WEE1

WEE1 G2 checkpoint kinase

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

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Products

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Target

WEE1 (2)

Reactivity

Human (2)

Mouse (2)

Rat (2)

Format

96-Well Microplate (2)

Publications

No (2)

Sample Type

Adherent Cell Cultures (2)

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Mouse/Human/Rat WEE1 (Cell-Based ELISA) ELISA Kit - LS-F2389

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat Phospho-WEE1 (Ser642) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1430

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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