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WDR82 / TMEM113
WD repeat domain 82
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
| Gene Name: | WD repeat domain 82 |
| Synonyms: | WDR82, MSTP107, PRO2730, PRO34047, Transmembrane protein 113, WD repeat domain 82, WDR82A, SWD2, MST107, TMEM113 |
| Target Sequences: | NM_025222 NP_079498.2 Q6UXN9 |
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