WDR61

WD repeat domain 61

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

WDR61 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Purified (1)

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Human WDR61 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68599

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.4 kDa

Price:

20 µg/$1,107

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Human WDR61 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82593

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.4 kDa

Price:

20 µg/$150

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Human WDR61 Protein (Recombinant GST) (Full Length) - LS-G35445

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59.29 kDa

Price:

10 µg/$479; 25 µg/$670

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WDR61 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109437

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.4 kDa

Price:

100 µg/$494

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