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WDR5

WD repeat domain 5

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

Gene Name:	WD repeat domain 5
Synonyms:	WDR5, BIG3, BIG-3, SWD3, WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat domain 5, WD-repeat protein 5
Target Sequences:	AJ011376 CAB66159.1 P61964

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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